Montana State University
Immunology & Infectious Diseases > Faculty > Mark Quinn, Professor and Chair

Mark Quinn, Professor and Chair

Immunology & Infectious Diseases
P.O. Box 173610
Montana State University
Bozeman, MT 59717
(406) 994-5721
mquinn@montana.edu

          Mark Quinn

Research Interests

Our research is focused on understanding microbicidal mechanisms utilized by innate immune cells in defense of the host against pathogens.  Specific projects are in progress to investigate the molecular and biochemical basis of phagocyte oxygen radical production, as well as the role of phagocyte-generated oxidants in the tissue damage associated with inflammatory diseases in humans and livestock.  Additional work focuses on identifying and characterizing novel immunomodulatory agents for enhancing innate immune responses.

Education

  • B.A. Point Loma College, San Diego, CA; 1982; Biology and Chemistry
  • Ph.D. University of California, San Diego, CA; 1987; Physiology and Pharmacology
  • Postdoctoral Fellow. Research Institute of Scripps Clinic, La Jolla, CA; 1987-1989; Biochemistry

Professional Experience

  • Research Institute of Scripps Clinic, La Jolla, CA; 2/88-6/89; Postdoctoral Research Associate
  • Montana State University, Bozeman; 7/89-12/90; Senior Research Associate
  • Montana State University, Bozeman; 1/91-3/31/95; Assistant & Associate Research Professor
  • Montana State University, Bozeman; 4/1/95-6/30/98; Assistant Professor
  • Montana State University, Bozeman; 7/1/98-present; Associate Professor
  • Montana State University, Bozeman; 7/1/00-7/31/01; Interim Department Head
  • Montana State University, Bozeman; 7/05-Present; Professor
  • Montana State University, Bozeman; 10/05-10/06; Interim Department Head
  • Montana State University, Bozeman; 11/06-Present; Department Head

Honors and Awards

  • 1980 Point Loma College President's Scholarship
  • 1981 Point Loma College Research Associates Summer Research Fellowship
  • 1982-1983 University of California Regents Fellowship
  • 1983-1986 National Science Foundation Graduate Fellowship
  • 1986-1987 San Diego and Graduate Opportunity Research Fellowship
  • 1987-1988 U.S. Public Health Service Predoctoral Traineeship
  • 1988-1989 U.S. Public Health Service Postdoctoral Traineeship
  • 1993 Charles and Nora Wiley Award for Meritorious Research
  • 1997-2000 Member National Arthritis Foundation Biochemistry Grant Study Section
  • 2000 Member MONTS Grant Review Panel
  • 2000 Invited International Bioethics Institute, Lisbon, Portugal
  • 2001-2003 Member National Arthritis Foundation Inflammation Grant Study Section
  • 2001 Invited Speaker, ASN/ISN World Congress of Nephrology, San Francisco, CA
  • 2002-2007 The Journal of Biological Chemistry Editorial Board
  • 2002 Invited Speaker, Oxidases in Inflammation & Cellular Signaling, Cold Spring Harbor
  • 2003-2005 Panelist USDA Competitive Grant Program Animal Health Study Section
  • 2003-2006 VA Merit Review Subcommittee for General Medical Sciences
  • 2004 NIH Special RFA Study Section Member
  • 2006 NIH ELB Study Section Ad Hoc Member
  • 2007 USDA Animal Biosecurity Coordinated Agricultural Project Study Section
  • 2008 Invited Speaker, Nox Family NADPH Oxidases Gordon Conference, New London, NH
  • 2009-2014 The Journal of Biological Chemistry Editorial Board
  • 2009-2013 The Journal of Leukocyte Biology Editorial Board

Extramural Grant Activity

  • 1989-1991 Arthritis Foundation Postdoctoral Fellowship
  • 1989 American Cancer Society Research Grant
  • 1991-1993 Arthritis Foundation Investigator Award
  • 1991-1993 American Lung Association Research Grant
  • 1992-1997 National Institutes of Health FIRST Award
  • 1994-1997 Arthritis Foundation Biomedical Science Grant
  • 1995-1998 USDA Competitive Research Grant
  • 1996-2001 American Heart Association Established Investigator Award
  • 1996-2001 National Institutes of Health R01
  • 1997-2000 Arthritis Foundation Biomedical Science Grant
  • 1997-1998 National Science Foundation Biological Instrumentation Grant
  • 1997-1998 USDA Shared Instrumentation Grant
  • 1998-1999 Baxter Healthcare Corporation Research Grant
  • 1999-2001 USDA Competitive Research Grant
  • 2000-2001 USDA Shared Instrumentation Grant
  • 2000-2002 USDA Competitive Research Grant
  • 2000-2004 National Institutes of Health R01
  • 2003-2009 National Institutes of Health R01
  • 2006-2007 USDA Shared Instrumentation Grant
  • 2007-2008 M.J. Murdock Charitable Trust
  • 2008-2014 NIH COBRE Program

Selected Publications

  1. Yang, Z., Asico, L.D., Yu, P., Wang, Z., Jones, J.E., Escano, C.S., Wang, X., Quinn, M.T., Romero, G.G., Sibley,  D.R., Felder, R.A., and Jose, P.A. (2006) D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290: R96-R104.
  2. Khlebnikov, A.I., Schepetkin, I., and Quinn, M.T. (2006) Quantitative Structure–Activity Relationships for Small Non-peptide Antagonists of CXCR2: Indirect 3D Approach Using the Frontal Polygon Method. Bioorg. Med. Chem. 14: 352-365.
  3. Gauss, K.A., Bunger, P.L., Larson, T.C., Crawford, M.A., McDermott, B., Swearingen, R., Nelson-Overton, L.K., Siemsen, D.W., and Quinn, M.T. (2006) Variants of the 5’-Untranslated Region of the Human NCF2 Message:  Expression and Translational Efficiency.  Gene 366: 169-179.
  4. Kondo, S., Shimizu, M., Urushihara, M., Tsuchiya, K., Yoshizumi, M., Tamaki, T., Nishiyama, A., Kawachi, H., Shimizu, F., Quinn, M.T., Lambeth, D.J., and Kagami, S. (2006) Addition of the Antioxidant Probucol to Angiotensin II Type I Receptor Antagonist Arrests Progressive Mesangioproliferative Glomerulonephritis in the Rat. J. Am. Soc. Nephrology 17: 783-794.
  5. Liu, M., Hanks, T.S., Zhang, J., McClure, M.J., Siemsen, D.W., Elser, J.L., Quinn, M.T., and Lei, B. (2006) Defects in ex vivo and in vivo growth and sensitivity to osmotic stress of group A Streptococcus caused by interruption of response regulator gene vicR. Microbiology 152: 967-978.
  6. Yang, X., Doser, T.A., Fang, C.X., Nunn, J.M., Janardhanan, R., Zhu, M., Sreejayan, N., Quinn, M.T., and Ren, J. (2006) Metallothionein Prolongs Survival and Antagonizes Senescence-Associated Cardiomyocyte Diastolic Dysfunction: Role of Oxidative Stress. FASEB J. 20: 1024-1026.
  7. Schepetkin, I., Potapov, A.S., Khlebnikov, A.I., Korotkova, E.I., Lukina, A.N., Kirpotina, L.N., and Quinn, M.T. (2006) Decomposition of Reactive Oxygen Species by Copper(II)-bis(1-pyrazolyl)methane Complexes. J. Biol. Inorg. Chem. 11: 499-513.
  8.  Marty, C., Kozasa, T., Quinn, M.T., and Ye, R.D. (2006) Activation state-dependent interaction between Gai and p67phox. Mol. Cell Biol. 26: 5190-5200.
  9.  Schepetkin, I., Khlebnikov, A.I., Kirpotina, L.N., and Quinn, M.T. (2006) Novel Small-molecule Inhibitors of Anthrax Lethal Factor Identified by High-throughput Screening. J. Med. Chem. 49: 5232-5244.
  10.  Khlebnikov, A.I., Schepetkin, I., Domina, N.G., Kirpotina, L.N., and Quinn, M.T. (2007) Improved Quantitative Structure-Activity Relationship Models to Predict Antioxidant Activity of Flavonoids in Chemical, Enzymatic and Cellular Systems.  Bioorg. Med. Chem. 15: 1749-1770.
  11. Schepetkin, I., Khlebnikov, A.I., Kirpotina, L.N., and Quinn, M.T. (2007) High-throughput Screening for Small-molecule Activators of Neutrophils: Identification of Novel N-Formyl Peptide Receptor Agonists.  Mol. Pharmacol. 71: 1061-1074.
  12. Ammons, M.C.B., Siemsen, D.W., Nelson-Overton, L.K., Quinn, M.T., and Gauss, K.A. (2007) Binding of Pleomorphic Adenoma Gene-Like 2 to the TNF-a-responsive Region of the NCF2 Promoter Regulates p67phox Expression and NADPH Oxidase Activity. J. Biol. Chem. 282: 17941-17952.
  13. Gauss, K.A., Nelson-Overton, L.K., Siemsen, D.W., Gao, Y., DeLeo, F.R., and Quinn, M.T. (2007) Role of NF-kB in Transcriptional Regulation of the Phagocyte NADPH Oxidase by Tumor Necrosis Factor a. J. Leukoc. Biol. 82: 729-741.
  14. Kawahara, T., Quinn, M.T., and Lambeth, J.D. (2007) Molecular Evolution of the Reactive Oxygen-Generating NADPH Oxidase (Nox/Duox) Family of Enzymes. BMC Evol. Biol. 7: 109.
  15. Schepetkin, I.A., Khlebnikov, A.I., and Quinn, M.T. (2007) N-Benzoylpyrazoles are Novel Small-Molecule Inhibitors of Human Neutrophil Elastase. J. Med. Chem. 50: 4928-4938.
  16. Xie, G., Schepetkin, I.A., and Quinn, M.T. (2007) Immunomodulatory Activity of Acidic Polysaccharides Isolated from Tanacetum vulgare L. Int. Immunopharmacol. 7: 1639-1650.
  17. Han, W., Li, H., Villar, V.A., Pascua, A.M., Dajani, M.I., Wang, X., Natarajan, A., Quinn, M.T., Felder, R.A., Jose, P.A., Yu, P. (2008) Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cells. Hypertension 51: 481-487.
  18. Mofarrahi, M., Brandes, R.P., Gorlach, A., Hanze, J., Terada, L.S., Quinn, M.T., Mayaki, D., Petrof, B., and Hussain, S.N. (2008) Regulation of Proliferation of Skeletal Muscle Precursor Cells by NADPH Oxidase. Antiox. Redox Signal. 10: 559-574.
  19. Khlebnikov, A.I., Schepetkin, I.A., and Quinn, M.T. (2008) Structure-Activity Relationship Analysis of N-Benzoylpyrazoles for Elastase Inhibitory Activity: A Simplified Approach Using Atom Pair Descriptors.  Bioorg. Med. Chem. 16: 2791-2802.
  20. Xie, G., Schepetkin, I.A., Siemsen, D.W., Kirpotina, L.N., Wiley, J.A., and Quinn, M.T. (2008) Fractionation and Characterization of Biologically-active Polysaccharides from Artemisia tripartita. Phytochemistry 69: 1359-1371.
  21. Nemali, S., Siemsen, D.W., Nelson, L.K., Bunger, P.L., Faulkner, C.L., Rainard, P., Gauss, K.A., Jutila, M.A., and Quinn, M.T. (2008) Molecular Analysis of the Bovine Anaphylatoxin C5a Receptor. J. Leukoc. Biol. 84: 537-549.
  22. Schepetkin, I.A., Kirpotina, L.N., Tian, J., Khlebnikov, A.I., Ye, R.D., and Quinn, M.T. (2008) Identification of Novel Formyl Peptide Receptor-Like 1 Agonists that Induce Macrophage Tumor Necrosis Factor α Production.  Mol. Pharmacol. 74: 392-402.
  23. Schepetkin, I.A., Xie, G., Kirpotina, L.N., Klein, R.A., Jutila, M.A., and Quinn, M.T. (2008) Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha. Int. Immunopharmacol. 8: 1455-1466.
  24. Khlebnikov, A.I., Schepetkin, I.A., Kirpotina, L.N., and Quinn, M.T. (2008) Computational Structure-Activity Relationship Analysis of Non-peptide Inducers of Macrophage Tumor Necrosis Factor-a Production. Bioorg. Med. Chem. 16: 9302-9312.
  25. Schepetkin, I.A., Xie, G., Jutila, M.A., and Quinn, M.T. (2009) Complement-fixing Activity of Humic Substances from Shilajit and Other Natural Sources. Phytother. Res. 23: 373-384.
  26. Raad, H., Paclet, M.H., Kroviarsky, Y., Morel, F., Quinn, M.T., Gougerot-Pocidalo, M.A., Dang, P.M., and El-Benna, J. (2009) Regulation of the Phagocyte NADPH Oxidase Activity: Phosphorylation of gp91phox/NOX2 by Protein Kinase C Enhances its Diaphorase Activity and Binding to Rac2, p67phox and p47phox. FASEB J. 23:1011-1022.
  27. Li, H., Han, W., Villar, V.A.M., Keever, L.B., Lu, Q., Hopfer, U., Quinn, M.T., Felder, R.A., Jose, P.A., and Yu, P. (2009) D1-like receptors regulate NADPH oxidase activity and subunit expression in lipid raft microdomains of renal proximal tubule cells. Hypertension 53: 1054-1061.
  28. Potapov, A.S., Nudnova, E.A., Domina, G.A., Kirpotina, L.N., Quinn, M.T., Khlebnikov, A.I., and Schepetkin, I.A. (2009) Synthesis, characterization and potent superoxide dismutase like activity of novel bis(pyrazole)–2,2¢-bipyridyl mixed ligand copper(II) complexes. Dalton Trans. 4488-4498.
  29. Siemsen, D.W., Jutila, M.A., and Quinn, M.T. (2009) Coxiella burnetii Phase II Inhibits Human Neutrophil NADPH Oxidase Assembly. Microbes Infect., In press.

Recent Reviews

  • Schepetkin, I. and Quinn, M.T. (2006) Botanical Polysaccharides: Macrophage Immunomodulation and Therapeutic Potential. Int. Immunopharmacol. 6: 317-333.
  • Quinn, M.T., Ammons, M.C.B., and DeLeo, F.R. (2006) The Expanding Role of NADPH Oxidases in Health and Disease: No Longer Just Agents of Death and Destruction.  Clinical Sci. 111: 1-20.
  • Quinn, M.T. and Schepetkin, I.A. (2009) Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells. J. Innate Immun., In press.